Epac protein wikipedia
How can the answer be improved?While protein kinase A (PKA) or cAMPdependent protein kinase and cyclic nucleotide regulated ion channel ( CNG and HCN) were initially unveiled in 1968 and 1985 respectively; EPAC genes were discovered in 1998 independently by two research groups. epac protein wikipedia
In addition to potentiating Ca 2 signaling through an effect on ryanodine receptors, Epac may bind Rim2, an effector of the small G protein Rab3 and another protein, Piccolo and mediate recruitment of secretory granules to release sites on the plasma membrane in a process known as priming (11, 22, 24, 37). A number of reviews are available on this subject (19, 25, 35).
Epac is a Rap1 factor directly activated by cyclic AMP. We have cloned the gene encoding a factor (GEF) which we have named Epac (exchange protein directly activated by cAMP). proteincoding gene in the species Caenorhabditis elegans. epac1 Q )epac protein wikipedia Using EPAC, suppliers of all sizes can equitably compete to win new business, and buyers can reduce costs, cut procurement time and reach more suppliers, says EPAC president and CEO Brian Cartwright.
Epac protein wikipedia free
Feb 06, 2009 It has now been over 10 years since efforts to completely understand the signalling actions of cAMP (35cyclic adenosine monophosphate) led to the discovery of exchange protein directly activated by cAMP (EPAC) proteins. epac protein wikipedia Epac enhances neurotransmitter release at the glutamatergic synapses of the rat brain calyx of Held and the crayfish neuromuscular junction. In dorsal root ganglion neurons, Epac mediates 2adrenergic receptorcAMP stimulation of protein kinase C (PKC) and mechanical hyperalgesia. Although important, these effects do not shed light on whether and how Epac could affect neuronal ion Elevation of cyclic AMP in Jurkat Tcells provokes distinct transcriptional responses through the protein kinase A (PKA) and exchange protein activated by cyclic AMP The discovery of Epac. Hormonal stimulation of many heterotrimeric Gproteincoupled receptors frequently results in the activation of adenylate cyclase and a subsequent increase in cAMP levels. cAMP is a second messenger that has roles in many physiological processes ranging from the regulation of heart rhythm, uptake of water in gut and kidney to memory. Not all protein kinases respond to cAMP. Several classes of protein kinases, including protein kinase C, are not cAMPdependent. Further effects mainly depend on cAMPdependent protein kinase, which vary based on the type of cell.
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